Neurology Main > Cognitive Division
ln

Cognitive Division
Memory Disorders Clinic
Memory Disorders Research Center
Clinical Trials
- SAGE Test
- 4 Turn Test
Dementia Resources
- Dementia Types
- ParentGiving Blog

Appointments and Referrals

Director
- Douglas Scharre, MD
Faculty
- Anahita Adeli, MD
- Shu-ing Chang, PharmD
- Rebecca Davis, RN, LISW
- Maria Kataki, MD, PhD
- Brendan Kelley, MD
- Renee Kovesci, MS, CNP
Research Staff
- Jennifer Icenhour, BA
- Kelly Ortman, BA
- Nicole Vrettos, BS
- Meredith Wessner, MA

Contact us at 614.293.4969

Dementia Types and Treatments

Alzheimer’s disease
Alzheimer’s accounts for 50 to 60 percent of the cases of dementia. It typically starts after age 50 and becomes more common as a person grows older. Death usually occurs six to 12 years after the onset of the disease. Sce4ientists have narrowed the cause of early-onset Alzheimer’s to three separate chromosomes and the onset of the more typical, age-related Alzheimer’s to one chromosome. Alzheimer’s starts quietly – that is, there are few or no symptoms to indicate anything is wrong. Early warning signs include difficulty with language and remembering things recently learned (such as a person’s name or directions to a particular place). As the disease progresses, so do the symptoms. Judgment is impaired, and the person has difficulty performing simple tasks. Behavioral symptoms may persist throughout the disease. About 70 percent of patients with the disease experience delusions of some sort, while depression affects about 40 percent. The only drugs currently approved for treating Alzheimer’s disease are called acetylcholinesterase inhibitors. Other drugs are on their way to the market, but are only effective for the early and middle stages of the disease and only provide a modest improvement in function.

Related links:
Alzheimer's Disease Research Fund
Alzheimer's Disease Four Turn Test
Memory Disorders Research Center

SAGE

Vascular dementia, or stroke
Multiple strokes are the second most common cause of dementia after Alzheimer’s disease. Over time, the patient becomes neurologically impaired. Usually there is a contributing factor, such as a history of hypertension, heart disease, diabetes or cigarette smoking. Physical symptoms include weakness, tremors and difficulty walking. Memory suffers, depression is frequent, and personality changes may occur. Controlling the risk factors of stroke – such as hypertension, diabetes, being overweight, smoking – is critical.

Binswanger’s disease
A form of vascular dementia that affects tiny blood vessels deep inside the brain. Dementia comes gradually with this disease. Symptoms include memory problems, mood changes and poor judgment.

Parkinson’s with dementia
Parkinson’s affects about 1 million Americans. Dementia is obvious in about 40 percent of patients with the disease, while an additional 50 percent have subtle signs of dementia. Dementia is most common in Parkinson’s patients with noticeable posture problems and walking difficulties. It is least common in patients with the characteristic tremors.

Diffuse Lewy body disease
It’s still a form of dementia that accompanies Parkinson’s disease, although the mental degradation is similar to that found in Alzheimer’s patients. Patients often appear rigid in their movement. The disease usually appears after age 60. Lewy bodies are abnormal cells that are found in the brain. For information on a study involving patients with diffuse Lewy body disease, please see the Memory Disorders Research Center.

Toxic-metabolic dementia
Prescribed drugs can cause dementia in the elderly. Looking over the patient’s medication regimen may reveal a reversible cause of dementia. Almost any drug can cause problems with mental function, but drugs in the following categories are particularly likely to cause problems:

Prescription drugs aside, alcohol can also cause dementia. As an alcoholic loses his memory capability, his mental processes slow down and his attention span decreases.

Other causes of toxic-metabolic dementia include:

Infectious dementia
A number of infectious agents can cause dementia in the elderly: fungi, parasites and viruses. Dementia can also occur with illnesses such as AIDS and Lyme disease.

Depression and Dementia
Certain patients with depression may show symptoms similar to dementia. The onset of dementia is gradual, and it’s reversible with the successful treatment of the mood disorder. Symptoms include a depressed mood, a slowing of mental processes and poor memory, as well as anxiety and agitation. Yet a patient’s memory usually isn’t affected.

Intervention and Treatments
Dementia brings with it many forms of disability. Patients with memory loss tend to underreport their symptoms, so illness may be overlooked. Infection and dehydration are quite common, as are adverse reactions to medications (particularly medication interactions.) Patients may need supervision to prevent falls, medication errors or poor eating habits. Prevent social and sensory deprivation by spending time with the patient. Support groups, family counseling and legal and social services can educate and help caregivers.

Disease-specific treatment (see Medications)

Behavioral Management
Doctors can treat changes in behavior caused by dementia. But it’s important to tailor the treatment to the individual, as his or her medical problems and medications need to be taken into account. If a patient’s behavior changes, check for infections and dehydration. It’s a good idea to maintain a routine, avoid unfamiliar places and relieve the patient’s pain. Ways to modify a patient’s behavior include being calm and gentle, using non-verbal communication, giving reassurance and acknowledging the patient’s concerns. Start medications at a low dose, and gradually increase to their optimal levels. Just remember that medications should be reviewed frequently and discontinued or reduced in dosage if necessary.

Treatment depends on the type of dementia a patient suffers from. In mild cases, where the behaviors don’t disturb the patient or the caregiver, then no treatment may be necessary. Otherwise, low-dose antipsychotics (link to Dementia Medications)may be helpful. For lasting agitation, irritability, aggression or violence, a low dose of an antipsychotic medication should be used. Patients that tend to move excessively – characterized by feeling restless, wandering, pacing or hiding objects – are best managed by providing a safe, contained environment. Also, regular exercise may reduce wandering.

See Medications for information on drugs used to treat specific types of dementia.