Herbert B. Newton, M.D., F.A.A.N. Herbert B. Newton is a Professor and Director, Division of Neuro-Oncology, Department of Neurology, The Ohio State University Hospitals and School of Medicine; Ester Dardinger Chair in Neuro-Oncology, Department of Neurology, The Ohio State University Hospitals and School of Medicine; Co-Director, Dardinger Neuro-Oncology Center, The Ohio State University Hospitals and School of Medicine; Professor, Department of Oncology, The Ohio State University Hospitals and School of Medicine; Attending, Neuro-Oncology, The Arthur G. James Cancer Hospital and Research Institute (CHRI); Graduate Faculty, Neuroscience Graduate Studies Program; Staff Physician, Section of Neurology, Department of Pediatrics, Children's Hospital of Columbus.

Biographical Sketch

Dr. Newton received his BA (magna cum laude, high honors in psychology) from SUNY at Buffalo Medical School in 1979 and his MS in 1980 in Natural Sciences - SUNY at Buffalo: Roswell Park Memorial Institute Division: "Interaction of Leucovorin with 5-FU in vivo and its effect on 5-FU toxicity." His M.D. is from SUNY at Buffalo in 1984.

Research

Dr. Newton has a specialty interest in brain tumors (oncology) and a research interest in malignant brain tumors.

Clinical Interests

brain tumors; oncology

Publications (Selected)

Medical Journals

Newton HB, Page MA, Junck L, Greenberg HS: Intra-arterial cisplatin for the treatment of malignant gliomas. J Neuro-Oncol 7: 39-45, 1989.

Newton HB, Page MA, Junck L, Bromberg J, Greenberg HS: Procarbazine chemotherapy in the treatment of recurrent malignant astrocytomas after radiation and nitrosourea failure. Neurology 40: 1743-1746, 1990.

Newton HB, Bromberg J, Junck L, Page MA, Greenberg HS: Comparison between BCNU and procarbazine chemotherapy for treatment of gliomas. J Neuro-Oncol 15: 257-263, 1993.

Newton HB: Primary brain tumors: Review of etiology, diagnosis, and treatment. Am Fam Phys 49: 787-797, 1994.

Newton HB, Newton C, Pearl DK, Davidson T: Swallowing assessment in primary brain tumor patients with dysphagia. Neurology 44: 1927-1932, 1994.

Newton HB: Common neurologic complications of HIV-1 infection and AIDS. Am Fam Phys 51: 387-398, 1995.

Newton HB, Newton CL, Gatens C, Hebert R, Pack R: Spinal cord tumors. Review of etiology, diagnosis, and multidisciplinary approach to treatment. Cancer Practice 3: 207-218, 1995.

Newton HB, Newton CL: Dose intensified cyclophosphamide, etoposide, and granulocyte colony-stimulating factor for treatment of malignant astrocytoma. J Neuro-Oncol 24: 285-292, 1995.

Newton HB, Shah SM: Neurological syndromes and emergencies in the cancer patient: Differential diagnosis, assessment protocols, and targeted clinical interventions. Emerg Med Reports 18: 149-158, 1997.

Newton HB, Malkin MG: Ethical issues in Neuro-Oncology. Semin Neurol 17: 219-226, 1997.

Newton HB: Neurological complications of systemic cancer. Amer Family Phys 59: 878-886, 1999.

Newton HB, Turowski RC, Stroup TJ, McCoy LK: Clinical presentation, diagnosis, and pharmacotherapy of patients with primary brain tumors. Ann Pharmacother 33: 816-832, 1999.

Gelman M, Chakeres D, Newton HB: Brain tumors: Complications of cerebral angiography accompanied by intra-arterial chemotherapy. Radiol 213: 135-140, 1999.

Newton HB, Fine HA, Spence A, and Grossman SA for Members of NCCN CNS Panel: NCCN clinical practice guidelines for non- immunosuppressed primary CNS lymphoma. Oncol 13: 153-160, 1999.

Newton HB, Slivka MA, Stevens C: Hydroxyurea chemotherapy for unresectable or residual meningioma. J Neuro-Oncol 49: 165-170, 2000.

Newton HB. Novel chemotherapeutic agents for the treatment of brain cancer. Expert Opin Investig Drugs 12: 2815-2829, 2000.

Newton HB. Neurological complications of scuba diving. Amer Family Phys 63: 2211-2218, 2001.

Newton HB, Snyder MA, Stevens C, Bourekas EC, Christoforidis GA, Baujan MA, Chakeres DW: Intra-arterial carboplatin and intravenous etoposide for the treatment of recurrent and progressive non-GBM gliomas. J Neuro-Oncol 56: 79-86, 2002.

Newton HB, Snyder MA, Stevens C, Bourekas EC, Christoforidis GA, Baujan MA, Chakeres DW, Slone W: Intra-arterial carboplatin and intravenous etoposide for the treatment of brain metastases. J Neuro-Oncol 61: 35-44, 2003.

Newton HB. Review of the molecular genetics and chemotherapeutic treatment of adult and pediatric medulloblastoma. Expert Opin Investig Drugs 10: 2089-2104, 2002.

Newton HB: Chemotherapy for the treatment of metastatic brain tumors. Expert Rev Anticancer Ther 2: 495-506, 2002.

Christoforidis GA, Grecula JC, Newton HB, Kangarlu A, Abduljalil AM, Schmallbrock P, Slone HW, Baujan MA, Bourekas EC, Chakeres DW: Visualization of microvascularity within glioblastoma multiforme utilizing 8 tesla high-resolution magnetic resonance imaging. AJNR Am J Neuroradiol 23: 1553-1556, 2002.

Grossman S, O’Neill A, Grunnet M, Mehta M, Pearlman JL, Wagner H, Gilbert M, Newton HB, Hellman R: Phase III study comparing three cycles of infusional carmustine and cisplatin followed by radiation therapy and concurrent carmustine in patients with newly diagnosed supratentorial glioblastoma multiforme: Eastern Cooperative Oncology Group Trial 2394. J Clin Oncol 21: 1485-1491, 2003

Newton HB: Molecular neuro-oncology and the development of “targeted” therapeutic strategies for brain tumors. Part 1 – growth factor and ras signaling pathways. Expert Rev Anticancer Ther 3: 595-614, 2003.

Newton HB: Molecular neuro-oncology and the development of “targeted” therapeutic strategies for brain tumors. Part 2 – PI3K/Akt/PTEN, mTOR, SHH/PTCH, and angiogenesis. Expert Rev Anticancer Ther 4: 105-128, 2004.

Medical Textbooks

Newton HB: Intracranial Neoplasms. In: Conn RB, Borer WZ, Snyder JW. Current Diagnosis 9. Philadelphia: W. B. Saunders, Co., 1997;10:843-849.

Newton HB: Brain Tumors and Other Neuro-Oncological Emergencies. In: Shah SM, Kelly KM (Eds). Emergency Neurology: Principles and Practice, 1999;23:326-341.

Newton HB: Chordoma. In: Raghavan D, Brecher M, Johnson DH, Meropol NJ, Moots PL, Thigpen JT. Textbook of Uncommon Cancers. 2nd Edition. 1999;21:279-289.

Newton HB: Neurology Grand Rounds - Current treatment of brain metastases. In: Gilman S, Goldstein G, Waxman S. Medlink Neurology: Computerized Database of Neurology (formerly Neurobase). CD ROM 2001.

Newton HB: Pilocytic Astrocytoma in Adults. In: Gilman S, Goldstein G, Waxman S. Medlink Neurology : Computerized Database of Neurology (formerly Neurobase). CD ROM 2003. (Updated and Revised).

Newton HB: Brainstem Gliomas in Adults. In: Gilman S, Goldstein G, Waxman S. Medlink Neurology : Computerized Database of Neurology (formerly Neurobase). CD ROM 2003. (Updated and Revised).

Newton HB: Sporadic Schwannomas and Neurofibromas. In: Gilman S, Goldstein G, Waxman S. Medlink Neurology: Computerized Database of Neurology (formerly Neurobase). CD ROM 2003. (Updated and Revised).

Newton HB: Chordomas. In: Gilman S, Goldstein G, Waxman S. Medlink Neurology: Computerized Database of Neurology (formerly Neurobase). CD ROM 2004 (Updated and Revised).

Newton HB: Supportive Care. In: Cancer of the Nervous System. O’Neill BO, Schiff D (Eds.) McGraw-Hill Publishers, 2004, (In Press)

The 5 Minute Neurology Consult. Lynn DJ, Newton HB, Rae-Grant A (Editors). Williams & Wilkins, Baltimore, 2004.

Contact

461 Means Hall
1654 Upham Drive
Columbus, Ohio 43210

Phone: 614-293-8930
Fax: 614-293-6111

email: newton.12@osu.edu